A phase I/II study of arfolitixorin and 5-fluorouracil in combination with oxaliplatin (plus or minus bevacizumab) or irinotecan in metastatic colorectal cancer

BACKGROUND: 5-fluorouracil (5-FU) combined with a folate remains an essential treatment component for metastatic colorectal cancer (mCRC). Leucovorin is the folate most often used, but requires intracellular conversion to a reduced folate, and has high pharmacokinetic variability and limited bioavai...

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Detalles Bibliográficos
Autores principales: Carlsson, G., Koumarianou, A., Guren, T.K., Haux, J., Katsaounis, P., Kentepozidis, N., Pfeiffer, P., Brændengen, M., Mavroudis, D., Taflin, H., Skintemo, L., Tell, R., Papadimitriou, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588906/
https://www.ncbi.nlm.nih.gov/pubmed/36183444
http://dx.doi.org/10.1016/j.esmoop.2022.100589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588906/
https://www.ncbi.nlm.nih.gov/pubmed/36183444
http://dx.doi.org/10.1016/j.esmoop.2022.100589

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