Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

Background: Bruton’s tyrosine kinase (BTK) inhibitors are commonly used in the targeted therapy of B-cell malignancies. It is reported that myelosuppression and fungal infections might occur during antitumor therapy of BTK inhibitors, therefore a combination therapy with triazole antifungals is usua...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Li, Chao, Bai, Hao, Li, Lixian, Chen, Wanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588929/
https://www.ncbi.nlm.nih.gov/pubmed/36299883
http://dx.doi.org/10.3389/fphar.2022.960186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588929/
https://www.ncbi.nlm.nih.gov/pubmed/36299883
http://dx.doi.org/10.3389/fphar.2022.960186

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