Cargando…

Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development

The accumulation and deposition of misfolded α-synuclein (α-Syn) aggregates in the brain is the central event in the pathogenesis of α-synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple-system atrophy. Currently, the diagnosis of these diseases mainly relies on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiaqi, Luo, Haiyang, Zheng, Honglin, Duan, Suying, Zhao, Taiqi, Yuan, Yanpeng, Liu, Yutao, Zhang, Xiaoyun, Wang, Yangyang, Yang, Jing, Xu, Yuming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588983/ https://www.ncbi.nlm.nih.gov/pubmed/36299857 http://dx.doi.org/10.3389/fnmol.2022.975619

Ejemplares similares

Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases
por: Duan, Suying, et al.
Publicado: (2023)

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
por: Okuzumi, Ayami, et al.
Publicado: (2023)

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
por: Yamasaki, Tritia R., et al.
Publicado: (2020)

Autonomic Dysfunction in α-Synucleinopathies
por: Mendoza-Velásquez, José Javier, et al.
Publicado: (2019)

Selective vulnerability in α-synucleinopathies
por: Alegre-Abarrategui, Javier, et al.
Publicado: (2019)

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
por: Williams, Tosha, et al.
Publicado: (2020)

Real-Time Quaking- Induced Conversion Assays for Prion Diseases, Synucleinopathies, and Tauopathies
por: Vascellari, Sarah, et al.
Publicado: (2022)

Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease
por: Miller, Sean J., et al.
Publicado: (2022)

Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants
por: Yang, Jing, et al.
Publicado: (2021)

Immunotherapies in Huntington's disease and α-Synucleinopathies
por: Fatoba, Oluwaseun, et al.
Publicado: (2020)

Neurons and Glia Interplay in α-Synucleinopathies
por: Mavroeidi, Panagiota, et al.
Publicado: (2021)

Autophagy in α-Synucleinopathies—An Overstrained System
por: Fellner, Lisa, et al.
Publicado: (2021)

Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation
por: Oueslati, Abid, et al.
Publicado: (2014)

ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson’s Disease-like Behavior
por: Gao, Fei, et al.
Publicado: (2022)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies
por: Caplan, Ian F., et al.
Publicado: (2018)

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Leukotriene Signaling as a Target in α-Synucleinopathies
por: Strempfl, Katharina, et al.
Publicado: (2022)

PPARs and Their Neuroprotective Effects in Parkinson’s Disease: A Novel Therapeutic Approach in α-Synucleinopathy?
por: Pérez-Segura, Isaac, et al.
Publicado: (2023)

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
por: Morgan, Sophie A., et al.
Publicado: (2020)

Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies
por: Kuzkina, A., et al.
Publicado: (2023)

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins
por: Marrero-Winkens, Cristóbal, et al.
Publicado: (2020)

Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
por: Sano, Kazunori, et al.
Publicado: (2017)

RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein
por: Srivastava, Ankit, et al.
Publicado: (2022)

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
por: Poggiolini, Ilaria, et al.
Publicado: (2021)

Disease modifying effect of adiponectin in model of α-synucleinopathies
por: Sekiyama, Kazunari, et al.
Publicado: (2014)

Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies
por: Lemos, Miguel, et al.
Publicado: (2020)

Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies
por: Shin, Junghwan, et al.
Publicado: (2020)

STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
por: Hinkle, Jared T., et al.
Publicado: (2022)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
por: Abdelkarim, Hazem, et al.
Publicado: (2018)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
por: Kawahata, Ichiro, et al.
Publicado: (2022)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
por: Schmitz, Matthias, et al.
Publicado: (2023)

α‐Synuclein Seed Amplification Assays in the Diagnosis of Synucleinopathies Using Cerebrospinal Fluid—A Systematic Review and Meta‐Analysis
por: Grossauer, Anna, et al.
Publicado: (2023)

Amyloidosis, Synucleinopathy, and Prion Encephalopathy in a Neuropathic Lysosomal Storage Disease: The CNS-Biomarker Potential of Peripheral Blood
por: Naughton, Bartholomew J., et al.
Publicado: (2013)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
por: Codolo, Gaia, et al.
Publicado: (2013)

Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy
por: Hoffmann, Alana, et al.
Publicado: (2019)

Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy
por: Sarkar, Souvarish, et al.
Publicado: (2020)

The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies
por: Leys, Fabian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fl05irb98mp41f25csq6v91br1