A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway

Neurofibromatosis type 2 is an autosomal dominant multiple neoplasia syndrome and is usually caused by mutations in the neurofibromin 2 (NF2) gene, which encodes a tumor suppressor and initiates the Hippo pathway. However, the mechanism by which NF2 functions in the Hippo pathway isn’t fully underst...

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Detalles Bibliográficos
Autores principales: Jia, Zexiao, Yang, Shuxu, Li, Mengyao, Lei, Zhaoying, Ding, Xue, Fan, Mingjie, Wang, Dixian, Xie, Dajiang, Zhou, Hui, Qiu, Yue, Zhuang, Qianqian, Li, Dan, Yang, Wei, Qi, Xuchen, Cang, Xiaohui, Zhao, Jing-Wei, Wang, Wenqi, Lin, Aifu, Yan, Qingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589172/
https://www.ncbi.nlm.nih.gov/pubmed/36300003
http://dx.doi.org/10.1016/j.isci.2022.105275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589172/
https://www.ncbi.nlm.nih.gov/pubmed/36300003
http://dx.doi.org/10.1016/j.isci.2022.105275

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