The N-terminal disease–associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches

Regulation of the neuronal microtubule cytoskeleton is achieved through the coordination of microtubule-associated proteins (MAPs). MAP-Tau, the most abundant MAP in the axon, functions to modulate motor motility, participate in signaling cascades, as well as directly mediate microtubule dynamics. T...

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Detalles Bibliográficos
Autores principales: Cario, Alisa, Wickramasinghe, Sanjula P., Rhoades, Elizabeth, Berger, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589210/
https://www.ncbi.nlm.nih.gov/pubmed/36162501
http://dx.doi.org/10.1016/j.jbc.2022.102526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589210/
https://www.ncbi.nlm.nih.gov/pubmed/36162501
http://dx.doi.org/10.1016/j.jbc.2022.102526

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