Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinct cellular actions suggesting divergence in downstream intrac...

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Detalles Bibliográficos
Autores principales: Zhao, Meng, Banhos Danneskiold-Samsøe, Niels, Ulicna, Livia, Nguyen, Quennie, Voilquin, Laetitia, Lee, David E, White, James P, Jiang, Zewen, Cuthbert, Nickeisha, Paramasivam, Shrika, Bielczyk-Maczynska, Ewa, Van Rechem, Capucine, Svensson, Katrin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592085/
https://www.ncbi.nlm.nih.gov/pubmed/36169399
http://dx.doi.org/10.7554/eLife.80014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592085/
https://www.ncbi.nlm.nih.gov/pubmed/36169399
http://dx.doi.org/10.7554/eLife.80014

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