Conformational changes and CO(2)-induced channel gating in connexin26

Connexins form large-pore channels that function either as dodecameric gap junctions or hexameric hemichannels to allow the regulated movement of small molecules and ions across cell membranes. Opening or closing of the channels is controlled by a variety of stimuli, and dysregulation leads to multi...

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Detalles Bibliográficos
Autores principales: Brotherton, Deborah H., Savva, Christos G., Ragan, Timothy J., Dale, Nicholas, Cameron, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592558/
https://www.ncbi.nlm.nih.gov/pubmed/35276081
http://dx.doi.org/10.1016/j.str.2022.02.010