Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to permanent hearing loss after HC death. Here, we used in vitro RNA-sequencing to show that the Hippo signaling pathway is involved in HC damage and self-repair processes. Turning off Hippo signaling through Mst1...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Xiaoling, Yu, Huiqian, Ma, Jiaoyao, Wang, Kunkun, Guo, Luo, Zhang, Yanping, Li, Boan, Zhao, Zehang, Li, Huawei, Sun, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592590/
https://www.ncbi.nlm.nih.gov/pubmed/36280668
http://dx.doi.org/10.1038/s41536-022-00261-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592590/
https://www.ncbi.nlm.nih.gov/pubmed/36280668
http://dx.doi.org/10.1038/s41536-022-00261-4

Ejemplares similares