Cargando…

Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to permanent hearing loss after HC death. Here, we used in vitro RNA-sequencing to show that the Hippo signaling pathway is involved in HC damage and self-repair processes. Turning off Hippo signaling through Mst1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xiaoling, Yu, Huiqian, Ma, Jiaoyao, Wang, Kunkun, Guo, Luo, Zhang, Yanping, Li, Boan, Zhao, Zehang, Li, Huawei, Sun, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592590/ https://www.ncbi.nlm.nih.gov/pubmed/36280668 http://dx.doi.org/10.1038/s41536-022-00261-4

Ejemplares similares

Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice
por: Zhang, Yanping, et al.
Publicado: (2012)

Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats
por: Zhao, Li-Dong, et al.
Publicado: (2011)

MiR-210 promotes sensory hair cell formation in the organ of corti
por: Riccardi, Sabrina, et al.
Publicado: (2016)

Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells
por: Elliott, Karen L., et al.
Publicado: (2018)

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
por: Xu, Jinshu, et al.
Publicado: (2017)

TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti
por: Kaiser, Marina, et al.
Publicado: (2022)

Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea
por: Zhang, Yanping, et al.
Publicado: (2018)

Inhibition of ferroptosis protects House Ear Institute‐Organ of Corti 1 cells and cochlear hair cells from cisplatin‐induced ototoxicity
por: Mei, Honglin, et al.
Publicado: (2020)

ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42
por: Sang, Qing, et al.
Publicado: (2015)

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss
por: Li, Guangfei, et al.
Publicado: (2018)

Characterization of Hair Cell-Like Cells Converted From Supporting Cells After Notch Inhibition in Cultures of the Organ of Corti From Neonatal Gerbils
por: Li, Yi, et al.
Publicado: (2018)

Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea
por: Taylor, Ruth R., et al.
Publicado: (2012)

Supervillin Is a Component of the Hair Cell’s Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells
por: Pollock, Lana M., et al.
Publicado: (2016)

CortiLove: A pilot study on hair steroids in the context of being in love and separation
por: Renner, Janis, et al.
Publicado: (2021)

Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
por: Liu, Huizhan, et al.
Publicado: (2016)

Increased mitochondrial DNA copy number protects hair cells and HEI-OC1 cells against drug-induced apoptosis
por: Mei, Honglin, et al.
Publicado: (2020)

Auditory Neural Plasticity in Tinnitus Mechanisms and Management
por: Wang, Kunkun, et al.
Publicado: (2020)

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures
por: Dammeyer, Pascal, et al.
Publicado: (2014)

MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells
por: Yousaf, Rizwan, et al.
Publicado: (2015)

Correction: Supervillin is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells
Publicado: (2016)

STK33 alleviates gentamicin‐induced ototoxicity in cochlear hair cells and House Ear Institute‐Organ of Corti 1 cells
por: Zhou, Meijuan, et al.
Publicado: (2018)

Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea
por: Ni, Wenli, et al.
Publicado: (2016)

Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea
por: Chen, Yan, et al.
Publicado: (2017)

Light at the end of the tunnel of Corti
por: Hanlon, Kilian, et al.
Publicado: (2023)

Multiple Sevoflurane Exposures During the Neonatal Period Cause Hearing Impairment and Loss of Hair Cell Ribbon Synapses in Adult Mice
por: Li, Yufeng, et al.
Publicado: (2022)

In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period
por: Sun, Shan, et al.
Publicado: (2014)

Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult
por: Chen, Yan, et al.
Publicado: (2013)

Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss
por: Zhang, Qian, et al.
Publicado: (2013)

Vestibular Dysfunctions in Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
por: Yu, Huiqian, et al.
Publicado: (2018)

Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.
por: Parker, Mark, et al.
Publicado: (2010)

Consequences of Location-Dependent Organ of Corti Micro-Mechanics
por: Liu, Yanju, et al.
Publicado: (2015)

Mechanically facilitated micro-fluid mixing in the organ of Corti
por: Shokrian, Mohammad, et al.
Publicado: (2020)

Organ of Corti vibrations are dominated by longitudinal motion in vivo
por: Meenderink, Sebastiaan W. F., et al.
Publicado: (2022)

Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti
por: Bai, Jun-Ping, et al.
Publicado: (2019)

Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti
por: Takeda, Hiroki, et al.
Publicado: (2021)

Behavioral characteristics in sensing mechanism of the Corti
por: Liang, Junyi, et al.
Publicado: (2023)

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner
por: Yang, Lu M., et al.
Publicado: (2019)

Molecular profile of cochlear immunity in the resident cells of the organ of Corti
por: Cai, Qunfeng, et al.
Publicado: (2014)

Structure and Mechanics of Supporting Cells in the Guinea Pig Organ of Corti
por: Zetes, Deborah E., et al.
Publicado: (2012)

A flexible anatomical set of mechanical models for the organ of Corti
por: Berger, Jorge, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0isknau7m49i5hl9l2etelc51i