Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins

Statins, a family of FDA-approved cholesterol-lowering drugs that inhibit the rate-limiting enzyme of the mevalonate metabolic pathway, have demonstrated anticancer activity. Evidence shows that dipyridamole potentiates statin-induced cancer cell death by blocking a restorative feedback loop trigger...

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Detalles Bibliográficos
Autores principales: van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592602/
https://www.ncbi.nlm.nih.gov/pubmed/36280687
http://dx.doi.org/10.1038/s41467-022-33144-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592602/
https://www.ncbi.nlm.nih.gov/pubmed/36280687
http://dx.doi.org/10.1038/s41467-022-33144-9

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