The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis

Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions. Methods: Studies comparing serum lipid...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xuerui, Zou, Yangbin, Zhang, Ruxuan, Teng, Chunyan, Ren, Xuejiao, Zhang, Haishan, Zhou, Liting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592854/
https://www.ncbi.nlm.nih.gov/pubmed/36304580
http://dx.doi.org/10.3389/fphys.2022.984586
_version_ 1784815023185461248
author Wang, Xuerui
Zou, Yangbin
Zhang, Ruxuan
Teng, Chunyan
Ren, Xuejiao
Zhang, Haishan
Zhou, Liting
author_facet Wang, Xuerui
Zou, Yangbin
Zhang, Ruxuan
Teng, Chunyan
Ren, Xuejiao
Zhang, Haishan
Zhou, Liting
author_sort Wang, Xuerui
collection PubMed
description Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions. Methods: Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test. Results: Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = −0.122 mmol/L, 95% CI: 0.170–0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061–0.299), 0.155 mmol/L (95% CI: 0.038–0.273), and 0.241 mmol/L (95% CI: 0.181–0.302), respectively. Conclusion: Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions.
format Online
Article
Text
id pubmed-9592854
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95928542022-10-26 The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis Wang, Xuerui Zou, Yangbin Zhang, Ruxuan Teng, Chunyan Ren, Xuejiao Zhang, Haishan Zhou, Liting Front Physiol Physiology Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions. Methods: Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test. Results: Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = −0.122 mmol/L, 95% CI: 0.170–0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061–0.299), 0.155 mmol/L (95% CI: 0.038–0.273), and 0.241 mmol/L (95% CI: 0.181–0.302), respectively. Conclusion: Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592854/ /pubmed/36304580 http://dx.doi.org/10.3389/fphys.2022.984586 Text en Copyright © 2022 Wang, Zou, Zhang, Teng, Ren, Zhang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Xuerui
Zou, Yangbin
Zhang, Ruxuan
Teng, Chunyan
Ren, Xuejiao
Zhang, Haishan
Zhou, Liting
The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title_full The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title_fullStr The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title_full_unstemmed The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title_short The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
title_sort relationship between serum lipid levels and colorectal serrated lesions: a systematic review and meta-analysis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592854/
https://www.ncbi.nlm.nih.gov/pubmed/36304580
http://dx.doi.org/10.3389/fphys.2022.984586
work_keys_str_mv AT wangxuerui therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zouyangbin therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhangruxuan therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT tengchunyan therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT renxuejiao therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhanghaishan therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhouliting therelationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT wangxuerui relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zouyangbin relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhangruxuan relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT tengchunyan relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT renxuejiao relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhanghaishan relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis
AT zhouliting relationshipbetweenserumlipidlevelsandcolorectalserratedlesionsasystematicreviewandmetaanalysis