Resistance profile and mechanism of severe acute respiratory syndrome coronavirus-2 variants to LCB1 inhibitor targeting the spike receptor-binding motif

LCB1 is a 56-mer miniprotein computationally designed to target the spike (S) receptor-binding motif of SARS-CoV-2 with potent in vitro and in vivo inhibitory activities (Cao et al., 2020; Case et al., 2021). However, the rapid emergence and epidemic of viral variants have greatly impacted the effec...

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Detalles Bibliográficos
Autores principales: Wu, Tong, Zhu, Yuanmei, Liu, Nian, Hu, Yue, Chong, Huihui, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593036/
https://www.ncbi.nlm.nih.gov/pubmed/36304946
http://dx.doi.org/10.3389/fmicb.2022.1022006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593036/
https://www.ncbi.nlm.nih.gov/pubmed/36304946
http://dx.doi.org/10.3389/fmicb.2022.1022006

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