Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8(+) antigen-specific T cells for adoptive immunotherapy

Antigen-specific T cell expansion ex vivo followed by adoptive transfer enables targeting of a multitude of microbial and cancer antigens. However, clinical-scale T cell expansion from rare precursors requires repeated stimulation, which may lead to T cell dysfunction and limited therapeutic potenti...

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Detalles Bibliográficos
Autores principales: Lak, Shirin, Janelle, Valérie, Djedid, Anissa, Boudreau, Gabrielle, Brasey, Ann, Lisi, Véronique, Smaani, Ali, Carli, Cédric, Busque, Lambert, Lavallée, Vincent-Philippe, Delisle, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593254/
https://www.ncbi.nlm.nih.gov/pubmed/36320412
http://dx.doi.org/10.1016/j.omtm.2022.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593254/
https://www.ncbi.nlm.nih.gov/pubmed/36320412
http://dx.doi.org/10.1016/j.omtm.2022.09.016

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