Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3

Genetic modification of coxsackievirus B3 (CVB3) by inserting target sequences (TS) of tumor-suppressive and/or organ-selective microRNAs (miRs) into viral genome can efficiently eliminate viral pathogenesis without significant impacts on its oncolytic activity. Nonetheless, reversion mutants (loss...

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Detalles Bibliográficos
Autores principales: Liu, Huitao, Bahreyni, Amirhossein, Mohamud, Yasir, Xue, Yuan Chao, Jia, William W.G., Luo, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593271/
https://www.ncbi.nlm.nih.gov/pubmed/36321136
http://dx.doi.org/10.1016/j.omto.2022.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593271/
https://www.ncbi.nlm.nih.gov/pubmed/36321136
http://dx.doi.org/10.1016/j.omto.2022.10.003

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