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Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3

Genetic modification of coxsackievirus B3 (CVB3) by inserting target sequences (TS) of tumor-suppressive and/or organ-selective microRNAs (miRs) into viral genome can efficiently eliminate viral pathogenesis without significant impacts on its oncolytic activity. Nonetheless, reversion mutants (loss...

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Detalles Bibliográficos
Autores principales:	Liu, Huitao, Bahreyni, Amirhossein, Mohamud, Yasir, Xue, Yuan Chao, Jia, William W.G., Luo, Honglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593271/ https://www.ncbi.nlm.nih.gov/pubmed/36321136 http://dx.doi.org/10.1016/j.omto.2022.10.003

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