Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome

NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that compares NEU-4438’s molecular modes of action to those of S...

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Detalles Bibliográficos
Autores principales: Sharma, Amrita, Cipriano, Michael, Ferrins, Lori, Hajduk, Stephen L., Mensa-Wilmot, Kojo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593816/
https://www.ncbi.nlm.nih.gov/pubmed/36304107
http://dx.doi.org/10.1016/j.isci.2022.105302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593816/
https://www.ncbi.nlm.nih.gov/pubmed/36304107
http://dx.doi.org/10.1016/j.isci.2022.105302

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