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Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome

NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that compares NEU-4438’s molecular modes of action to those of S...

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Detalles Bibliográficos
Autores principales:	Sharma, Amrita, Cipriano, Michael, Ferrins, Lori, Hajduk, Stephen L., Mensa-Wilmot, Kojo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593816/ https://www.ncbi.nlm.nih.gov/pubmed/36304107 http://dx.doi.org/10.1016/j.isci.2022.105302

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