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Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

Loss of innervation is a key driver of age associated muscle atrophy and weakness (sarcopenia). Our laboratory has previously shown that denervation induced atrophy is associated with the generation of mitochondrial hydroperoxides and lipid mediators produced downstream of cPLA(2) and 12/15 lipoxyge...

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Detalles Bibliográficos
Autores principales: Brown, Jacob L., Peelor, Fredrick F., Georgescu, Constantin, Wren, Jonathan D., Kinter, Michael, Tyrrell, Victoria J., O'Donnell, Valerie B., Miller, Benjamin F., Van Remmen, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593840/
https://www.ncbi.nlm.nih.gov/pubmed/36283174
http://dx.doi.org/10.1016/j.redox.2022.102518