Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction

Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. These biochemical and cell biological mechanisms for Aβ-induc...

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Detalles Bibliográficos
Autores principales: Lucero, Esteban M., Freund, Ronald K., Smith, Alexandra, Johnson, Noah R., Dooling, Breanna, Sullivan, Emily, Prikhodko, Olga, Ahmed, Md. Mahiuddin, Bennett, David A., Hohman, Timothy J., Dell’Acqua, Mark L., Chial, Heidi J., Potter, Huntington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593841/
https://www.ncbi.nlm.nih.gov/pubmed/36304124
http://dx.doi.org/10.1016/j.isci.2022.105288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593841/
https://www.ncbi.nlm.nih.gov/pubmed/36304124
http://dx.doi.org/10.1016/j.isci.2022.105288

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