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Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice

With the recent findings that mutations in the gene encoding the α-subunit of calcium/calmodulin-dependent protein kinase II (CAMK2A) causes a neurodevelopmental disorder (NDD), it is of great therapeutic relevance to know if there exists a critical developmental time window in which CAMK2A needs to...

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Detalles Bibliográficos
Autores principales: Rigter, Pomme M.F., Wallaard, Ilse, Aghadavoud Jolfaei, Mehrnoush, Kingma, Jenina, Post, Laura, Elgersma, Minetta, Elgersma, Ype, van Woerden, Geeske M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593899/
https://www.ncbi.nlm.nih.gov/pubmed/36304100
http://dx.doi.org/10.1016/j.isci.2022.105303