Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

[Image: see text] While there has been recent success in the development of KRas(G12C) inhibitors, unmet needs for selective inhibitors of KRas(G12D) and the remaining oncogenic KRas proteins remain. Here, we applied trifluoromethyl-containing ligands of KRas proteins as competitive probe ligands to...

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Detalles Bibliográficos
Autores principales: Peacock, D. Matthew, Kelly, Mark J. S., Shokat, Kevan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594042/
https://www.ncbi.nlm.nih.gov/pubmed/36166818
http://dx.doi.org/10.1021/acschembio.2c00566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594042/
https://www.ncbi.nlm.nih.gov/pubmed/36166818
http://dx.doi.org/10.1021/acschembio.2c00566

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