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Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

[Image: see text] While there has been recent success in the development of KRas(G12C) inhibitors, unmet needs for selective inhibitors of KRas(G12D) and the remaining oncogenic KRas proteins remain. Here, we applied trifluoromethyl-containing ligands of KRas proteins as competitive probe ligands to...

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Detalles Bibliográficos
Autores principales:	Peacock, D. Matthew, Kelly, Mark J. S., Shokat, Kevan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594042/ https://www.ncbi.nlm.nih.gov/pubmed/36166818 http://dx.doi.org/10.1021/acschembio.2c00566

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