High-level dolutegravir resistance can emerge rapidly from few variants and spread by recombination: implications for integrase strand transfer inhibitor salvage therapy

The integrase strand transfer inhibitor (INSTI) dolutegravir is commonly used in combination antiretroviral therapy regimens and retains strong potency even with primary resistance mutations to some other INSTIs. Acquisition of accessory mutations to primary mutations results in significant increase...

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Detalles Bibliográficos
Autores principales: Huik, Kristi, Hill, Shawn, George, Jomy, Pau, Alice, Kuriakose, Safia, Lange, Camille M., Dee, Nicola, Stoll, Pamela, Khan, Muhammad, Rehman, Tauseef, Rehm, Catherine A., Dewar, Robin, Grossman, Zehava, Maldarelli, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Clinical Science: Concise Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594130/
https://www.ncbi.nlm.nih.gov/pubmed/35848510
http://dx.doi.org/10.1097/QAD.0000000000003288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594130/
https://www.ncbi.nlm.nih.gov/pubmed/35848510
http://dx.doi.org/10.1097/QAD.0000000000003288

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