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Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease

[Image: see text] The α-aminophosphonate UAMC-00050, a newly developed trypsin-like serine protease inhibitor, is a lead compound for the treatment of dry eye syndrome and ocular inflammation. The medicinal chemistry route developed at the University of Antwerp possessed several problems hampering t...

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Detalles Bibliográficos
Autores principales: Ceradini, Davide, Cacivkins, Pavel, Ramos-Llorca, Alba, Shubin, Kirill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594321/
https://www.ncbi.nlm.nih.gov/pubmed/36311379
http://dx.doi.org/10.1021/acs.oprd.2c00244