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Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease
INTRODUCTION: Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). METHODS: Seventy‐one p...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594557/ https://www.ncbi.nlm.nih.gov/pubmed/36304723 http://dx.doi.org/10.1002/trc2.12356 |
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author | Nakaya, Moto Sato, Noriko Matsuda, Hiroshi Maikusa, Norihide Shigemoto, Yoko Sone, Daichi Yamao, Tensho Ogawa, Masayo Kimura, Yukio Chiba, Emiko Ohnishi, Masahiro Kato, Koichi Okita, Kyoji Tsukamoto, Tadashi Yokoi, Yuma Sakata, Masuhiro Abe, Osamu |
author_facet | Nakaya, Moto Sato, Noriko Matsuda, Hiroshi Maikusa, Norihide Shigemoto, Yoko Sone, Daichi Yamao, Tensho Ogawa, Masayo Kimura, Yukio Chiba, Emiko Ohnishi, Masahiro Kato, Koichi Okita, Kyoji Tsukamoto, Tadashi Yokoi, Yuma Sakata, Masuhiro Abe, Osamu |
author_sort | Nakaya, Moto |
collection | PubMed |
description | INTRODUCTION: Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). METHODS: Seventy‐one participants underwent multi‐shell diffusion MRI, (18)F‐THK5351 PET, (11)C‐Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD‐spectrum group (AD‐S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores. RESULTS: In AD‐S group, there was a significant positive correlation between FW and (18)F‐THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between (18)F‐THK5351 and cognitive function in the same regions. DISCUSSION: FW imaging could be a biomarker for tau in AD alongside clinical correlations. |
format | Online Article Text |
id | pubmed-9594557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95945572022-10-26 Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease Nakaya, Moto Sato, Noriko Matsuda, Hiroshi Maikusa, Norihide Shigemoto, Yoko Sone, Daichi Yamao, Tensho Ogawa, Masayo Kimura, Yukio Chiba, Emiko Ohnishi, Masahiro Kato, Koichi Okita, Kyoji Tsukamoto, Tadashi Yokoi, Yuma Sakata, Masuhiro Abe, Osamu Alzheimers Dement (N Y) Research Articles INTRODUCTION: Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). METHODS: Seventy‐one participants underwent multi‐shell diffusion MRI, (18)F‐THK5351 PET, (11)C‐Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD‐spectrum group (AD‐S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores. RESULTS: In AD‐S group, there was a significant positive correlation between FW and (18)F‐THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between (18)F‐THK5351 and cognitive function in the same regions. DISCUSSION: FW imaging could be a biomarker for tau in AD alongside clinical correlations. John Wiley and Sons Inc. 2022-10-25 /pmc/articles/PMC9594557/ /pubmed/36304723 http://dx.doi.org/10.1002/trc2.12356 Text en © 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Nakaya, Moto Sato, Noriko Matsuda, Hiroshi Maikusa, Norihide Shigemoto, Yoko Sone, Daichi Yamao, Tensho Ogawa, Masayo Kimura, Yukio Chiba, Emiko Ohnishi, Masahiro Kato, Koichi Okita, Kyoji Tsukamoto, Tadashi Yokoi, Yuma Sakata, Masuhiro Abe, Osamu Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title_full | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title_fullStr | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title_full_unstemmed | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title_short | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
title_sort | free water derived by multi‐shell diffusion mri reflects tau/neuroinflammatory pathology in alzheimer's disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594557/ https://www.ncbi.nlm.nih.gov/pubmed/36304723 http://dx.doi.org/10.1002/trc2.12356 |
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