APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease

BACKGROUND: The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition during the seeding stage of amyloid developm...

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Detalles Bibliográficos
Autores principales: Kim, Hongwon, Kim, Siyoung, Cho, Byounggook, Shin, Jaein, Kim, Jongpil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594913/
https://www.ncbi.nlm.nih.gov/pubmed/36284363
http://dx.doi.org/10.1186/s40035-022-00319-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594913/
https://www.ncbi.nlm.nih.gov/pubmed/36284363
http://dx.doi.org/10.1186/s40035-022-00319-9

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