Cargando…
APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease
BACKGROUND: The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition during the seeding stage of amyloid developm...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594913/ https://www.ncbi.nlm.nih.gov/pubmed/36284363 http://dx.doi.org/10.1186/s40035-022-00319-9 |