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KUALA: a machine learning-driven framework for kinase inhibitors repositioning

The family of protein kinases comprises more than 500 genes involved in numerous functions. Hence, their physiological dysfunction has paved the way toward drug discovery for cancer, cardiovascular, and inflammatory diseases. As a matter of fact, Kinase binding sites high similarity has a double rol...

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Detalles Bibliográficos
Autores principales: De Simone, Giada, Sardina, Davide Stefano, Gulotta, Maria Rita, Perricone, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595087/
https://www.ncbi.nlm.nih.gov/pubmed/36284125
http://dx.doi.org/10.1038/s41598-022-22324-8