Cargando…

Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells

Over-expression of genetically encoded thioredoxin reductase 1 (TrxR1) TrxR1 can be toxic to cells due to the formation of a truncated version of the enzyme. We developed a new mammalian cell-based model to investigate TrxR1 activity. Fusion of the HIV-derived cell penetrating peptide (TAT) enabled...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, David E., Siddika, Tarana, Heinemann, Ilka U., O’Donoghue, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595596/ https://www.ncbi.nlm.nih.gov/pubmed/36304926 http://dx.doi.org/10.3389/fmolb.2022.1031756

Ejemplares similares

Editorial: Small molecule inhibitors targeting mammalian selenoprotein thioredoxin reductases (TXNRDs): Interactions, mechanisms, and applications
por: Xu, Jianqiang, et al.
Publicado: (2023)

Expanding codon size
por: Siddika, Tarana, et al.
Publicado: (2022)

Delivery of Active AKT1 to Human Cells
por: Siddika, Tarana, et al.
Publicado: (2022)

Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation
por: Wright, David. E., et al.
Publicado: (2021)

Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells
por: Zhang, Junmin, et al.
Publicado: (2021)

Thioredoxin Reductase Inhibitors as Potential Antitumors: Mercury Compounds Efficacy in Glioma Cells
por: Pires, Vanessa, et al.
Publicado: (2022)

Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity
por: Wright, David E., et al.
Publicado: (2018)

Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway
por: Jiao, Wenxuan, et al.
Publicado: (2021)

miRNA-Dependent Regulation of AKT1 Phosphorylation
por: Frederick, Mallory I., et al.
Publicado: (2022)

Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone
por: Shu, Nan, et al.
Publicado: (2019)

MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1
por: Kline, Chelsey D., et al.
Publicado: (2022)

Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme
por: Smith, Madison M., et al.
Publicado: (2023)

Bringing MicroRNAs to Light: Methods for MicroRNA Quantification and Visualization in Live Cells
por: Siddika, Tarana, et al.
Publicado: (2021)

Exposure to Silver Nanoparticles Inhibits Selenoprotein Synthesis and the Activity of Thioredoxin Reductase
por: Srivastava, Milan, et al.
Publicado: (2011)

The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance
por: Jovanović, Mirna, et al.
Publicado: (2022)

Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins
por: Morosky, Pearl, et al.
Publicado: (2023)

The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
por: Tsuji, Petra A., et al.
Publicado: (2015)

Synergism between a foldase and an unfoldase: reciprocal dependence between the thioredoxin-like activity of DnaJ and the polypeptide-unfolding activity of DnaK
por: Mattoo, Rayees U. H., et al.
Publicado: (2014)

Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer
por: Méplan, Catherine, et al.
Publicado: (2012)

UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins
por: Turanov, Anton A., et al.
Publicado: (2013)

Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus
por: Fata, Francesca, et al.
Publicado: (2022)

Comprehensive overview of the role of PBX1 in mammalian kidneys
por: Zou, Fei, et al.
Publicado: (2023)

Synthetic DNA and RNA Programming
por: O’Donoghue, Patrick, et al.
Publicado: (2019)

Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase
por: Jenny, Kaelyn A., et al.
Publicado: (2022)

Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
por: Redzic, Jasmina S., et al.
Publicado: (2021)

Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle
por: Lee, Eunjeong, et al.
Publicado: (2023)

Substrate Specificity of Cysteine Proteases Beyond the S(2) Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L
por: Corvo, Ileana, et al.
Publicado: (2018)

Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis
por: Dos Santos, Fernando, et al.
Publicado: (2023)

Development of Methodology to Investigate the Surface SMALPome of Mammalian Cells
por: Morrison, Kerrie A., et al.
Publicado: (2021)

Circular Ribonucleic Acid circFTO Promotes Angiogenesis and Impairs Blood–Retinal Barrier Via Targeting the miR-128-3p/Thioredoxin Interacting Protein Axis in Diabetic Retinopathy
por: Guo, Jianjin, et al.
Publicado: (2021)

Editorial: Synthetic Nucleic Acids for Expanding Genetic Codes and Probing Living Cells
por: O'Donoghue, Patrick, et al.
Publicado: (2021)

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design
por: Fiorillo, Annarita, et al.
Publicado: (2022)

In Vitro Folliculogenesis in Mammalian Models: A Computational Biology Study
por: Bernabò, Nicola, et al.
Publicado: (2021)

Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
por: Ruano, Diego
Publicado: (2021)

The structural and functional roles of the flavin cofactor FAD in mammalian cryptochromes
por: Calloni, Giulia, et al.
Publicado: (2023)

Involvement of HB-EGF/Ascl1/Lin28a Genes in Dedifferentiation of Adult Mammalian Müller Glia
por: Stanchfield, Megan L., et al.
Publicado: (2020)

Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?
por: Lothrop, Adam P., et al.
Publicado: (2014)

Chlorophyllin Inhibits Mammalian Thioredoxin Reductase 1 and Triggers Cancer Cell Death
por: Sun, Shibo, et al.
Publicado: (2021)

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components
por: Faoro, Camilla, et al.
Publicado: (2021)

3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors
por: Manabe, Noriyoshi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_guq7hkqsahv1durb0ug61ju3ud