The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

Antisense oligonucleotides (ASOs) that mediate RNA target degradation by RNase H1 are used as drugs to treat various diseases. Previously we found that introduction of a single 2′-O-methyl (2′-OMe) modification in position 2 of the central deoxynucleotide region of a gapmer phosphorothioate (PS) ASO...

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Detalles Bibliográficos
Autores principales: Zhang, Lingdi, Liang, Xue-hai, De Hoyos, Cheryl Li, Migawa, Michael, Nichols, Joshua G., Freestone, Graeme, Tian, Jun, Seth, Punit P., Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595634/
https://www.ncbi.nlm.nih.gov/pubmed/35861704
http://dx.doi.org/10.1089/nat.2022.0005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595634/
https://www.ncbi.nlm.nih.gov/pubmed/35861704
http://dx.doi.org/10.1089/nat.2022.0005

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