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Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)
Drugs that directly impede the function of driver oncogenes offer exceptional efficacy and a therapeutic window. The recently approved mutant selective small-molecule cysteine-reactive covalent inhibitor of the G12C mutant of K-Ras, sotorasib, provides a case in point. KRAS is the most frequently mu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596369/ https://www.ncbi.nlm.nih.gov/pubmed/35864332 http://dx.doi.org/10.1038/s41589-022-01065-9 |