Discovery and molecular basis of subtype-selective cyclophilin inhibitors

Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel cyclophilin inhibitors from the in vitro selection of a DNA-templated library of 256,000 drug-like macrocycles for cyclo...

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Detalles Bibliográficos
Autores principales: Peterson, Alexander A., Rangwala, Aziz M., Thakur, Manish K., Ward, Patrick S., Hung, Christie, Outhwaite, Ian R., Chan, Alix I., Usanov, Dmitry L., Mootha, Vamsi K., Seeliger, Markus A., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596378/
https://www.ncbi.nlm.nih.gov/pubmed/36163383
http://dx.doi.org/10.1038/s41589-022-01116-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596378/
https://www.ncbi.nlm.nih.gov/pubmed/36163383
http://dx.doi.org/10.1038/s41589-022-01116-1

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