mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity

Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the mTOR kinase, a master regulator of metabolism, as an early host resistance fac...

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Detalles Bibliográficos
Autores principales: Pagán, Antonio J., Lee, Lauren J., Edwards-Hicks, Joy, Moens, Cecilia B., Tobin, David M., Busch-Nentwich, Elisabeth M., Pearce, Erika L., Ramakrishnan, Lalita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596383/
https://www.ncbi.nlm.nih.gov/pubmed/36103894
http://dx.doi.org/10.1016/j.cell.2022.08.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596383/
https://www.ncbi.nlm.nih.gov/pubmed/36103894
http://dx.doi.org/10.1016/j.cell.2022.08.018

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