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mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the mTOR kinase, a master regulator of metabolism, as an early host resistance fac...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596383/ https://www.ncbi.nlm.nih.gov/pubmed/36103894 http://dx.doi.org/10.1016/j.cell.2022.08.018 |