Cargando…

Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist

In Alzheimer's disease pathology, several neuronal processes are dysregulated by excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic agents capable of modulating such processes are needed to foster neuroprotection. Here, the effect of an optimised NMDA receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Companys-Alemany, Júlia, Turcu, Andreea L., Vázquez, Santiago, Pallàs, Mercè, Griñán-Ferré, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596444/ https://www.ncbi.nlm.nih.gov/pubmed/36284170 http://dx.doi.org/10.1038/s41598-022-22963-x

Ejemplares similares

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2020)

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2021)

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection
por: Griñan-Ferré, Christian, et al.
Publicado: (2016)

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease
por: Bellver-Sanchis, Aina, et al.
Publicado: (2021)

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models
por: Jarne-Ferrer, Júlia, et al.
Publicado: (2022)

Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline
por: Cosín-Tomás, Marta, et al.
Publicado: (2018)

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model
por: Griñán-Ferré, Christian, et al.
Publicado: (2019)

Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents
por: Bellver‐Sanchis, Aina, et al.
Publicado: (2022)

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy
por: Pallàs, Mercè, et al.
Publicado: (2020)

Cognitive Decline and BPSD Are Concomitant with Autophagic and Synaptic Deficits Associated with G9a Alterations in Aged SAMP8 Mice
por: Vasilopoulou, Foteini, et al.
Publicado: (2022)

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model
por: Vasilopoulou, Foteini, et al.
Publicado: (2021)

Correction: Izquierdo et al. Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Int. J. Mol. Sci. 2021, 22, 1453
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
por: Griñán-Ferré, Christian, et al.
Publicado: (2016)

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2020)

Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2020)

The Role of the miR-17-92 Cluster in Autophagy and Atherosclerosis Supports Its Link to Lysosomal Storage Diseases
por: Ortuño-Sahagún, Daniel, et al.
Publicado: (2022)

Reply to Nifli, A.-P. Comment on “Rosell-Cardona et al. Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice. Nutrients 2021, 13, 2369”
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer′s Disease Neurodegeneration
por: Bartra, Clara, et al.
Publicado: (2022)

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I(2)-Imidazoline Receptor Ligand MCR5
por: Vasilopoulou, Foteini, et al.
Publicado: (2020)

Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
por: Izquierdo, Vanesa, et al.
Publicado: (2019)

NMDA Receptors in Glial Cells: Pending Questions
por: Dzamba, David, et al.
Publicado: (2013)

Modulation of Functional EEG Networks by the NMDA Antagonist Nitrous Oxide
por: Kuhlmann, Levin, et al.
Publicado: (2013)

Neuroprotective Effects of Resveratrol by Modifying Cholesterol Metabolism and Aβ Processing in SAMP8 Mice
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2022)

Inhibition of NMDA receptors through a membrane-to-channel path
por: Wilcox, Madeleine R., et al.
Publicado: (2022)

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis
por: Rosell-Cardona, Cristina, et al.
Publicado: (2022)

The Computer Simulation of Therapy with the NMDA Antagonist in Excitotoxic Neurodegeneration in an Alzheimer’s Disease-like Pathology
por: Świetlik, Dariusz, et al.
Publicado: (2022)

NMDA Receptor Antagonists for Treatment of Depression
por: Ates-Alagoz, Zeynep, et al.
Publicado: (2013)

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
por: Torres, Eva, et al.
Publicado: (2012)

High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease
por: Bouvier, David S., et al.
Publicado: (2016)

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins
por: Avila, Jesús, et al.
Publicado: (2017)

Allosteric antagonist action at triheteromeric NMDA receptors
por: Gibb, Alasdair J.
Publicado: (2022)

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease
por: Codony, Sandra, et al.
Publicado: (2022)

Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease
por: Bagán, Andrea, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0a0bdpgsi0c5b6276h0tq20iv3