Diffusive drug delivery in the brain extracellular space from a cellular scale microtube

The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs d...

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Autores principales: Störi, Marie-Joe, Oluwasanya, Pelumi W., Proctor, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Early Career Materials Researcher Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596563/
https://www.ncbi.nlm.nih.gov/pubmed/36312901
http://dx.doi.org/10.1557/s43579-022-00247-9
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author Störi, Marie-Joe
Oluwasanya, Pelumi W.
Proctor, Christopher M.
author_facet Störi, Marie-Joe
Oluwasanya, Pelumi W.
Proctor, Christopher M.
author_sort Störi, Marie-Joe
collection PubMed
description The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1557/s43579-022-00247-9.
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spelling pubmed-95965632022-10-27 Diffusive drug delivery in the brain extracellular space from a cellular scale microtube Störi, Marie-Joe Oluwasanya, Pelumi W. Proctor, Christopher M. MRS Commun Early Career Materials Researcher Research Letter The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1557/s43579-022-00247-9. Springer International Publishing 2022-09-19 2022 /pmc/articles/PMC9596563/ /pubmed/36312901 http://dx.doi.org/10.1557/s43579-022-00247-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Early Career Materials Researcher Research Letter
Störi, Marie-Joe
Oluwasanya, Pelumi W.
Proctor, Christopher M.
Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title_full Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title_fullStr Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title_full_unstemmed Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title_short Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
title_sort diffusive drug delivery in the brain extracellular space from a cellular scale microtube
topic Early Career Materials Researcher Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596563/
https://www.ncbi.nlm.nih.gov/pubmed/36312901
http://dx.doi.org/10.1557/s43579-022-00247-9
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