Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators

This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene. Eighteen compounds were synthesised and confirmed their NRF2 activation through NQO1 enzymatic activity and mRNA expression of NQ...

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Detalles Bibliográficos
Autores principales: Mak, Kit‐Kay, Shiming, Zhang, Epemolu, Ola, Dinkova‐Kostova, Albena T., Wells, Geoffrey, Gazaryan, Irina G., Sakirolla, Raghavendra, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596610/
https://www.ncbi.nlm.nih.gov/pubmed/36284193
http://dx.doi.org/10.1002/open.202200181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596610/
https://www.ncbi.nlm.nih.gov/pubmed/36284193
http://dx.doi.org/10.1002/open.202200181

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