The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection

SMER28 originated from a screen for small molecules that act as modulators of autophagy. SMER28 enhanced the clearance of autophagic substrates such as mutant huntingtin, which was additive to rapamycin-induced autophagy. Thus, SMER28 was established as a positive regulator of autophagy acting indep...

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Detalles Bibliográficos
Autores principales: Kirchenwitz, Marco, Stahnke, Stephanie, Grunau, Kyra, Melcher, Lars, van Ham, Marco, Rottner, Klemens, Steffen, Anika, Stradal, Theresia E. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596692/
https://www.ncbi.nlm.nih.gov/pubmed/36284196
http://dx.doi.org/10.1038/s41598-022-20563-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596692/
https://www.ncbi.nlm.nih.gov/pubmed/36284196
http://dx.doi.org/10.1038/s41598-022-20563-3

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