The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside

Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- and lifespan across species. However, effective gen...

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Detalles Bibliográficos
Autores principales: Birkisdóttir, María B., van Galen, Ivar, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T., Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G., Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H. J., Dollé, Martijn E. T., Vermeij, Wilbert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596940/
https://www.ncbi.nlm.nih.gov/pubmed/36313181
http://dx.doi.org/10.3389/fragi.2022.1005322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596940/
https://www.ncbi.nlm.nih.gov/pubmed/36313181
http://dx.doi.org/10.3389/fragi.2022.1005322

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