Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC

The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear. We exploited HCT116 cancer cell line to select resistant clones to S-trityl-L-cysteine (STLC), an extensively studied...

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Detalles Bibliográficos
Autores principales: Indorato, Rose-Laure, DeBonis, Salvatore, Garcia-Saez, Isabel, Skoufias, Dimitrios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597087/
https://www.ncbi.nlm.nih.gov/pubmed/36313676
http://dx.doi.org/10.3389/fonc.2022.965455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597087/
https://www.ncbi.nlm.nih.gov/pubmed/36313676
http://dx.doi.org/10.3389/fonc.2022.965455

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