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Fuzzy optimization for identifying anti-cancer targets with few side effects in constraint-based models of head and neck cancer
Computer-aided methods can be used to screen potential candidate targets and to reduce the time and cost of drug development. In most of these methods, synthetic lethality is used as a therapeutic criterion to identify drug targets. However, these methods do not consider the side effects during the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597175/ https://www.ncbi.nlm.nih.gov/pubmed/36303939 http://dx.doi.org/10.1098/rsos.220633 |