Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders

The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic reticulum Ca(2+) release required for skeletal and cardiac muscle contraction. Mutations in RyR1 and RyR2 lead to life-threatening malignant hyperthermia episodes and ventricular tachycardia, respectively. In this brief...

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Detalles Bibliográficos
Autores principales: Zhang, Yadan, Rabesahala de Meritens, Camille, Beckmann, Astrid, Lai, F. Anthony, Zissimopoulos, Spyros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597452/
https://www.ncbi.nlm.nih.gov/pubmed/36311249
http://dx.doi.org/10.3389/fphys.2022.1032132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597452/
https://www.ncbi.nlm.nih.gov/pubmed/36311249
http://dx.doi.org/10.3389/fphys.2022.1032132

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