Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27

Interleukin-27 (IL-27) uniquely assembles p28 and EBI3 subunits to a heterodimeric cytokine that signals via IL-27Rα and gp130. To provide the structural framework for receptor activation by IL-27 and its emerging therapeutic targeting, we report here crystal structures of mouse IL-27 in complex wit...

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Detalles Bibliográficos
Autores principales: Składanowska, Katarzyna, Bloch, Yehudi, Strand, Jamie, White, Kerry F., Hua, Jing, Aldridge, Daniel, Welin, Martin, Logan, Derek T., Soete, Arne, Merceron, Romain, Murphy, Casey, Provost, Mathias, Bazan, J. Fernando, Hunter, Christopher A., Hill, Jonathan A., Savvides, Savvas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597551/
https://www.ncbi.nlm.nih.gov/pubmed/36261006
http://dx.doi.org/10.1016/j.celrep.2022.111490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597551/
https://www.ncbi.nlm.nih.gov/pubmed/36261006
http://dx.doi.org/10.1016/j.celrep.2022.111490

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