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Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27
Interleukin-27 (IL-27) uniquely assembles p28 and EBI3 subunits to a heterodimeric cytokine that signals via IL-27Rα and gp130. To provide the structural framework for receptor activation by IL-27 and its emerging therapeutic targeting, we report here crystal structures of mouse IL-27 in complex wit...
Autores principales: | Składanowska, Katarzyna, Bloch, Yehudi, Strand, Jamie, White, Kerry F., Hua, Jing, Aldridge, Daniel, Welin, Martin, Logan, Derek T., Soete, Arne, Merceron, Romain, Murphy, Casey, Provost, Mathias, Bazan, J. Fernando, Hunter, Christopher A., Hill, Jonathan A., Savvides, Savvas N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597551/ https://www.ncbi.nlm.nih.gov/pubmed/36261006 http://dx.doi.org/10.1016/j.celrep.2022.111490 |
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