Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis

Concurrent mutation of a RAS oncogene and the tumor suppressor p53 is common in tumorigenesis, and inflammation can promote RAS-driven tumorigenesis without the need to mutate p53. Here, we show, using a well-established mutant RAS and an inflammation-driven mouse skin tumor model, that loss of the...

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Detalles Bibliográficos
Autores principales: Al Moussawi, Khatoun, Chung, Kathryn, Carroll, Thomas M., Osterburg, Christian, Smirnov, Artem, Lotz, Rebecca, Miller, Paul, Dedeić, Zinaida, Zhong, Shan, Oti, Martin, Kouwenhoven, Evelyn N., Asher, Ruth, Goldin, Robert, Tellier, Michael, Murphy, Shona, Zhou, Huiqing, Dötsch, Volker, Lu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597577/
https://www.ncbi.nlm.nih.gov/pubmed/36261000
http://dx.doi.org/10.1016/j.celrep.2022.111503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597577/
https://www.ncbi.nlm.nih.gov/pubmed/36261000
http://dx.doi.org/10.1016/j.celrep.2022.111503

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