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Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry

BACKGROUND: Identifying T cell epitopes on pancreatic ductal adenocarcinoma (PDAC) associated antigens or neoantigens has been a challenge. In this study, we attempted to identify PDAC T cell epitopes by mass spectrometry (MS). METHODS: We isolated HLA class I (HLA-I) and HLA class II (HLA-II)-restr...

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Detalles Bibliográficos
Autores principales: Fujiwara, Kenji, Shao, Yingkuan, Niu, Nan, Zhang, Tengyi, Herbst, Brian, Henderson, Mackenzie, Muth, Stephen, Zhang, Pingbo, Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597957/
https://www.ncbi.nlm.nih.gov/pubmed/36284347
http://dx.doi.org/10.1186/s13045-022-01373-6