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HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cells

BACKGROUND: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors. HB-EGF and its receptors, epidermal growth factor receptor (EGFR) and HER4, are expressed in the human corpus luteum. HB-EGF has been shown to regula...

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Detalles Bibliográficos
Autores principales: Cheng, Jung-Chien, Han, Xiaoyu, Meng, Qingxue, Guo, Yanjie, Liu, Boqun, Song, Tinglin, Jia, Yuanyuan, Fang, Lanlan, Sun, Ying-Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598000/
https://www.ncbi.nlm.nih.gov/pubmed/36284301
http://dx.doi.org/10.1186/s12964-022-00983-4