Glutathione–Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells’ Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis

Hemin, an oxidized form of heme, acts as potent oxidant to regulate glutathione (GSH) content in pro-erythroid K562 nucleated cells, via activation of the KEAP1/NRF2 defensive signaling pathway. Moreover, GSH, as an essential metabolite, is involved in the regulation of cell-redox homeostasis and pr...

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Detalles Bibliográficos
Autores principales: Georgiou-Siafis, Sofia K., Samiotaki, Martina K., Demopoulos, Vassilis J., Panayotou, George, Tsiftsoglou, Asterios S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598195/
https://www.ncbi.nlm.nih.gov/pubmed/36290682
http://dx.doi.org/10.3390/antiox11101959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598195/
https://www.ncbi.nlm.nih.gov/pubmed/36290682
http://dx.doi.org/10.3390/antiox11101959

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