Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline

Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by reverse electron transfer (RET) from the ubiquinone (UQ) pool. Glutathionylation of complex I does induce increased mitochondrial superoxide/hydrogen peroxide (O(2)(●−)/H(2)O(2)) production, but the source of th...

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Detalles Bibliográficos
Autores principales: Wang, Kevin, Hirschenson, Jonathan, Moore, Amanda, Mailloux, Ryan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598259/
https://www.ncbi.nlm.nih.gov/pubmed/36290766
http://dx.doi.org/10.3390/antiox11102043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598259/
https://www.ncbi.nlm.nih.gov/pubmed/36290766
http://dx.doi.org/10.3390/antiox11102043

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