Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway

Excessive reactive oxygen species (ROS) production leads to oxidative stress in cells, impairing the function of mitochondria and finally inducing cell apoptosis. Considering the essential role of oxidative stress in the pathogenesis of various neurodegenerative diseases and psychiatric disorders, t...

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Detalles Bibliográficos
Autores principales: Xiong, Liang, Wu, Hongshan, Zhong, Ting, Luo, Fang, Li, Qing, Li, Mei, Fan, Yanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598289/
https://www.ncbi.nlm.nih.gov/pubmed/36290737
http://dx.doi.org/10.3390/antiox11102014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598289/
https://www.ncbi.nlm.nih.gov/pubmed/36290737
http://dx.doi.org/10.3390/antiox11102014

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